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Methods in Bioengineering: Microdevices in Biology and Medicine
Yaakov Nahmias, Mass General Hospital/Harvard Medical School and Sangeeta Bhatia, MIT, Editors
ISBN 978-1-59693-404-7
Copyright 2009
Pages: 365
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  • Description
  • Editors
  • Contents

Microfabrication technology has quietly changed the world around us. Hiding under the shiny coat of our cars, cellular phones, and music players, the silicon microchip markedly changed our way of life. Features a thousand times smaller than a single millimeter enable an unparallel control over electrical signals resulting in nearly magical computational, communication, and memory powers. At the dawn of this century, a similar revolution is changing the study of biology and the practice of medicine. Microscale patterns, three-dimensional features, and the physics of small places offer a unique ability to control the microenvironment providing innovative tools for the study, diagnosis and treatment of disease. Offering a practical look into the field, this volume presents the science behind microscale device design and the engineering of its fabrication. Supported with dozens of full-color illustrations, this book offers you clear, step-by-step methods for:

  • Cell capture from whole blood
  • High-throughput study of transcriptional dynamics in living cells
  • Temporal control of cell-cell interaction
  • Nanoscale measurements of cellular forces
  • Immobilizing living c. elegans
  • Optical and electrical on-chip cell sorting
  • Human-on-chip modeling of drug metabolism

    • Related Titles
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    Methods in Bioengineering: Alternative Technologies to Animal Testing by Tim Maguire and Eric Novik, Editors
    Methods in Bioengineering: 3D Tissue Engineering by Francois Berthiaume and Jeffrey Morgan, Editors
    Methods in Bioengineering: Biomicrofabrication and Biomicrofluidics by Jeffrey D. Zahn, Editor
    Methods in Bioengineering: Systems Analysis of Biological Networks by Arul Jayaraman and Juergen Hahn, Editors
    Methods in Bioengineering: Nanoscale Bioengineering and Nanomedicine by Kaushal Rege and Igor L. Medintz, Editors
    Methods in Bioengineering: Stem Cell Bioengineering by Biju Parekkadan and Martin Yarmush, Editors

    Yaakov Nahmias is an instructor in Surgery and Bioengineering at the BioMEMs Resource Center at Massachusetts General Hospital, Harvard Medical School. He is a senior lecturer at the School of Computer Science and Engineering at the Hebrew University of Jerusalem, and an associate member of the Center for Bioengineering in the Service of Humanity. Dr. Nahmias holds a B.Sc. in chemical engineering from the Technion-Israel Institute of Technology and a Ph.D. in biomedical engineering from the University of Minnesota.

    Sangeeta Bhatia is a Howard Hughes Medical Institute Investigator and a professor in the Department of Health Sciences and Technology, as well as the Department of Electrical Engineering and Computer Science, at MIT. She is associate member of the Broad Institute and Brigham & Women’s Hospital and the director of the Laboratory for Multiscale Regenerative Technologies. Dr. Bhatia holds an M.D. from Harvard Medical School and a Ph.D. in medical engineering from the Harvard-MIT Division of Health Sciences and Technology.

    Immunoaffinity Capture of Cells from Whole Blood. Dynamic Gene Expression Analysis in a Living Cell Array. Micromechanical Control of Cell-Cell Interactions. Mechanotransduction and the Study of Cellular Forces. A Microfluidic Tool for Immobilizing C. Elegans. Osmolality Control for Microfluidic Embryo Cell Culture using Hybrid poly(dimethylsiloxane)(PDMS)-Parylene Membranes. Image-Based Cell Sorting using Microscale Electrical and Optical Actuation. Pharmacokinetic-Pharmacodynamic Models on a Chip. Lab-on-a-chip Impedance Detection of Microbial and Cellular Activity. Controlling the Cellular Microenvironment. Subtractive Methods for Forming Microfluidic Gels of Extracellular Matrix Proteins.

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