“This is the first book to provide an expert and timely comprehensive overview of the present and future outlook of clinical multimodality optical imaging from the academic to the industrial perspective. Written by pioneers in the field, it will become a useful reference to clinicians and non-clinicians, researchers, scientists, educators and students.” – Britton Chance, Ph.D., ScD.
Written by pioneers in the field, this first-of-its-kind resource on multimodal optical imaging provides you with a rigorous treatment of the various techniques together with the latest clinical advances in cancer detection and other important applications. You find full details on the principles, instrumentation, and methods of in vivo microscopy, optical coherence tomography, endoscopy, and diffuse optical techniques.
Supported with 119 illustrations, this milestone work discusses key optical imaging techniques in self-contained chapters; describes the integration of optical imaging techniques with other modalities like MRI, X-ray imaging, and PET imaging; provides a software platform for multimodal integration; presents cutting-edge computational and data processing techniques that ensure rapid, cost-effective, and precise quantification and characterization of the clinical data; covers advances in photodynamic therapy and molecular imaging, and reviews key clinical studies in optical imaging along with regulatory and business issues.
Software Included
Contains three freely installable software platforms for development of advanced applications, as well as full-color images and videos that further illustrate topics discussed in the book.
Overview of Optical Methods — Optical imaging technique. Optical contrast origin. In-vivo microscopy. OCT. Endoscopy. Diffuse optical techniques.
In-Vivo Microscopy — Overview of optical microscopy technique on bench. Technique applied to in-vivo. Challenge-future.
Optical Coherence Tomography — Principles. Instrumentation. Clinical applications. Challenge-future.
Endoscopy — Principles-relevance. Different methods. Clinical scenarios. Challenge-future.
Diffuse Optical Techniques: Instrumentation — Overview of different approaches. Current survey of clinical apparatus. Challenge-future.
Diffuse Optical Techniques: Theory — Diffusion equation. DOS. DOT. Assisted DOS-DOT. Challenge-future.
Diffuse Optical Imaging for Cancer Detection — Physiology. Breast cancer. Therapy monitoring. Other cancers. Challenge-future.
A Software Platform for Integration of Optical Imaging and Other Modalities — Multimodal MR/X-Ray/DOT integration. MR/DOT experimentation. DOS integration using a tracking system for handheld devices. Challenges-future.
Optical Imaging and MRI — Relevance/significance. Specific instrumentation. Specific data processing. Challenges. Challenge-future.
Optical Imaging and X-Ray Imaging — Relevance/significance. Specific instrumentation. Specific data processing. Challenges-future.
Optical Imaging and PET Imaging — Relevance/significance. Specific instrumentation. Specific data processing. Challenges. Future.
Photodynamic Therapy — Principles. Instrumentation. Clinical Applications. Challenges-future.
Building Phantoms for Optical Imaging and Multimodal Imaging — Relevance/significance. Methods. Challenges. Future.
Clinical Studies in Optical Imaging: An Industry Perspective — Relevance/significance. Methods. Challenges. Future.
Business and Regulations — Business case. ISO regulations. FDA regulations. Defining standard as a community. Validating an optical system in clinical trials. Challenge-future.
Molecular Imaging — Relevance/significance. Actual exogenous agent used in clinical settings. Pre-clinical work. Challenge-future.
The Future of Optical Imaging in the Clinic: Enablers and Barriers to Entry
Fred S. Azar is the external projects lead and a scientific investigator in the Department of Imaging and Visualization at Siemens Corporate Research Inc., Princeton, NJ. Dr. Azar led the team that developed the first software prototype platform for integrating multimodal optical imaging data with X-ray mammography and magnetic resonance images of the breast. He holds more than 15 provisional patents/patents, and has worked for several leading institutions such as Sarnoff Corp., the Montreal Neurological Institute, and GE Medical Systems. Dr. Azar earned a Ph.D. in bioengineering at the University of Pennsylvania, and is pursuing an M.B.A. at the Wharton School.
Xavier Intes is an assistant professor in the Department of Biomedical Engineering at the Rensselaer Polytechnic Institute (RPI), Troy, New York. Prior to joining RPI, Dr. Intes was the chief scientist of Advanced Research Technologies Inc., Canada, a leader in optical molecular imaging. He has cowritten more than 80 peer reviewed papers in the field, holds numerous patents in the field, and serves as a reviewer for several science and engineering journals, including Applied Optics, Optics Express, Medical Physics, JOSA A, Journal of Biomedical Optics, Technology in Cancer Research and Treatment, Optics Letters, IEEE Transactions in Medical Imaging, Neuroimage, and the Proceedings of the National Academy of Sciences. He received a Ph.D. in physics from the Université de Bretagne Occidentale, France.
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